The use of human cell lines and primary cells as in vitro models represents a valuable
approach to study cellular responses to infection. However, with the advent of new …

Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB)
disease, which involves the transformation of infected phagolysosomes from a site of killing …

Functional genomics is the use of systematic gene perturbation approaches to determine the
contributions of genes under conditions of interest. Although functional genomic strategies …

All cells contain specialized signaling pathways that enable adaptation to specific molecular
stressors. Yet, whether these pathways are centrally regulated in complex physiological …

Macrophages are a protective replicative niche for Mycobacterium tuberculosis (Mtb) but can
kill the infecting bacterium when appropriately activated. To identify mechanisms of …

Histone deacetylases (HDACs) are critical immune regulators. However, their roles in
interleukin-1β (IL-1β) production remain unclear. By screening 11 zinc-dependent HDACs …

Mycobacteria are responsible for a heavy global disease burden, but their relative genetic
intractability has long frustrated research efforts. The introduction of clustered regularly …

结核病是一种古老的传染病, 在有效药物发现之前结核病的发病率及病死率都非常高.
近一百年来陆续发现链霉素, 异烟肼, 吡嗪酰胺, 乙胺丁醇, 利福平等一系列经典抗结核化学药物 …

Sophisticated gene circuits built by synthetic biology can enable bacteria to sense their
environment and respond predictably. Biosensing bacteria can potentially probe the human …

Regenerative medicine, a therapeutic approach using stem cells, aims to rejuvenate and
restore the normalized function of the cells, tissues, and organs that are injured …