Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90
countries in the world. More than 20 Leishmania species cause different forms of …

Human monocytes have been grouped into classical (CD14++ CD16−), non-classical
(CD14dimCD16++), and intermediate (CD14++ CD16+) subsets. Documentation of normal …

The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus
Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites …

Leishmaniasis is a neglected tropical disease that affects 12 million people worldwide. The
disease has high morbidity and mortality rates and is prevalent in over 80 countries, leaving …

Macrophages respond to changes in environmental stimuli by assuming distinct functional
phenotypes, a phenomenon referred to as macrophage polarization. We generated …

Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, presents an
exaggerated Th1 response that is associated with ulcer development. Macrophages are the …

Tissue-resident memory T cells are required for establishing protective immunity against a
variety of different pathogens, although the mechanisms mediating protection by CD4+ …

Inflammatory monocytes can be manipulated by environmental cues to perform multiple
functions. To define the role of monocytes during primary or secondary infection with an intra …