The emerging roles of ac4C acetylation “writer” NAT10 in tumorigenesis: A comprehensive review

L Wang, Y Tao, J Zhai, M Xue, C Zheng, H Hu - International Journal of …, 2023 - Elsevier
The quick progress of epigenetic study has kindled new hope for treating many cancers.
When it comes to RNA epigenetics, the ac4C acetylation modification is showing promise …

Recent advancements in the use of Bobbitt's salt and 4-acetamidoTEMPO

JM Bray, SM Stephens, SM Weierbach… - Chemical …, 2023 - pubs.rsc.org
Recent advances in synthetic methodologies for selective, oxidative transformations using
Bobbitt's salt (4-acetamido-2, 2, 6, 6-tetramethyl-1-oxopiperidinium tetrafluoroborate, 1) and …

Bioorthogonal labeling and profiling of N6-isopentenyladenosine (i6A) modified RNA

Y Li, H Zhou, S Chen, Y Li, Y Guo, X Chen… - Nucleic Acids …, 2024 - academic.oup.com
Chemical modifications in RNAs play crucial roles in diversifying their structures and
regulating numerous biochemical processes. Since the 1990s, several hydrophobic prenyl …

Photo‐Facilitated Detection and Sequencing of 5‐Formylcytidine RNA

XY Jin, ZR Huang, LJ Xie, L Liu, DL Han… - Angewandte …, 2022 - Wiley Online Library
Formylcytidine (f5C) is one of the epigenetic nucleotides in tRNA. Despite the evident
importance of f5C in gene expression regulation, little is known about its exact amount and …

A Light‐Controllable Chemical Modulation of m6A RNA Methylation

L Lan, YJ Sun, XY Jin, LJ Xie, L Liu… - Angewandte …, 2021 - Wiley Online Library
Bioactive small molecules with photo‐removable protecting groups have provided spatial
and temporal control of corresponding biological effects. We present the design, synthesis …

Sequential azidation/azolation of prenylated derivatives and a click reaction enable selective labeling and degradation of RAS protein

Y Gan, X Chen, Y Li, Y Guo… - The Journal of Organic …, 2023 - ACS Publications
We propose the introduction of the azido and azo-functionalities into prenylated derivatives
under mild conditions in a selective and efficient way. Upon protocol establishment and …

A Bioorthogonal Post-modification of N6-Isopentenyl Adenosine i6A RNA in Live Cells

LJ Xie, HP Cheng, MY Chen, X Wang, L Liu… - CCS …, 2024 - chinesechemsoc.org
Selective methods for modulating RNA epigenetic modifications within living cells and
organisms represent attractive techniques for investigating biological functions and …

Selective Methylation of Nucleosides via an In Situ Generated Methyl Oxonium

XY Jin, YM He, TH Hui, L Liu… - The Journal of Organic …, 2024 - ACS Publications
A very mild and efficient procedure has been developed for the preparation of N-methylated
uridine, pseudouridine, guanosine and inosine derivatives. This process was compatible …

Chemical pulldown of Prenylated-Adenosine-Incorporated RNA via sequential Fluorination-Azidation and a click reaction targeting prenyl functionality

X Chen, Y Gan, Y Guo, Y Li, H Zhou, R Wang - Tetrahedron Letters, 2024 - Elsevier
In recent years, modified nucleotides have attracted widespread attention in the field of
chemical biology, biochemistry and beyond. Although some achievements have been made …

N6‐Isopentenyladenosine in RNA Determines the Cleavage Site of Endonuclease Deoxyribozymes

A Liaqat, C Stiller, M Michel, MV Sednev… - Angewandte …, 2020 - Wiley Online Library
RNA‐cleaving deoxyribozymes can serve as selective sensors and catalysts to examine the
modification state of RNA. However, site‐specific endonuclease deoxyribozymes that …