Matrix metalloproteinases (MMPs) are a diverse group of proteolytic enzymes and play an
important role in the degradation and remodeling of the extracellular matrix (ECM). In normal …

Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that
function through the extracellular matrix (ECM). They are involved in diverse …

Repeated noise exposure induces inflammation and cellular adaptations in the peripheral
and central auditory system resulting in pathophysiology of hearing loss. In this study, we …

Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in
regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many …

Conclusion: Noise exposure can cause a decline in cochlear ribbon synapses and result in
consequent hearing loss. The reduction of synaptic puncta appears reversible and may …

In the sensory epithelium, macrophages have been identified on the scala tympani side of
the basilar membrane. These basilar membrane macrophages are the spatially closest …

The immune response is an important component of the cochlear response to stress. As an
important player in the cochlear immune system, the basilar membrane immune cells reside …

Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve
deterioration, resulting in transient or permanent hearing loss depending on the exposure …

Acoustic overstimulation traumatizes the cochlea, resulting in auditory dysfunction. As a
consequence of acoustic injury, the immune system in the cochlea is activated, leading to …

Our previous RNA-sequencing analysis of the rat cochlear genes identified multiple
biological processes and molecular pathways in the cochlear response to acoustic …