Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Clinical development of metal complexes as photosensitizers for photodynamic therapy of cancer

J Karges - Angewandte chemie international edition, 2022 - Wiley Online Library
Cancer has emerged over the last decades as one of the deadliest diseases in the world.
Among the most commonly used techniques (ie surgery, immunotherapy, radiotherapy or …

Photocatalytic superoxide radical generator that induces pyroptosis in cancer cells

L Yu, Y Xu, Z Pu, H Kang, M Li… - Journal of the …, 2022 - ACS Publications
Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing
attention as a promising approach to cancer immunotherapy. However, biocompatible …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Type I photosensitizers revitalizing photodynamic oncotherapy

D Chen, Q Xu, W Wang, J Shao, W Huang, X Dong - Small, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …

Photodecaging of a mitochondria-localized iridium (III) endoperoxide complex for two-photon photoactivated therapy under hypoxia

S Kuang, F Wei, J Karges, L Ke, K Xiong… - Journal of the …, 2022 - ACS Publications
Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …

[HTML][HTML] An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers

J An, S Tang, G Hong, W Chen, M Chen, J Song… - Nature …, 2022 - nature.com
The most common working mechanism of photodynamic therapy is based on high-toxicity
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …

Latest developments in metal complexes as anticancer agents

R Paprocka, M Wiese-Szadkowska… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …

An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐and Immuno‐Therapy of Cancer

M Zhao, Y Zhang, J Miao, H Zhou, Y Jiang… - Advanced …, 2024 - Wiley Online Library
Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an
effective cancer treatment because of its hypoxia‐tolerant superiority over the commonly …