Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …

The word “biocompatibility,” is inconsistent with the observations of healing for so‐called
biocompatible biomaterials. The vast majority of the millions of medical implants in humans …

This essay analyzes the scientific evidence that forms the basis of bioactive materials,
covering the fundamental understanding of bioactivity phenomena and correlation with the …

Macrophages as the main cause of cancer immunosuppression, how to effectively induce
macrophage M1 polarization remain the major challenge in lung cancer therapy. Herein …

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have
debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress …

Macrophage immunotherapy represents an emerging therapeutic approach aimed at
modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have …

Cardiovascular tissue constructs provide unique design requirements due to their functional
responses to substrate mechanical properties and cyclic stretching behavior of cardiac …

Innate immunity is the first line of defense against invading pathogens. Innate immune cells
can recognize invading pathogens through recognizing pathogen-associated molecular …

Despite current efforts in organ‐on‐chip engineering to construct miniature cardiac models,
they often lack some physiological aspects of the heart, including fiber orientation. This …

The field of immunology is undergoing rapid and dramatic changes. Immunometabolism, a
change in metabolic pathways within immune cells, is a key determinant in the activation of …