[HTML][HTML] Testicular cancer: Determinants of cisplatin sensitivity and novel therapeutic opportunities
G de Vries, X Rosas-Plaza, MATM van Vugt… - Cancer Treatment …, 2020 - Elsevier
Testicular cancer (TC) is the most common solid tumor among men aged between 15 and
40 years. TCs are highly aneuploid and the 12p isochromosome is the most frequent …
40 years. TCs are highly aneuploid and the 12p isochromosome is the most frequent …
Germline stem cells in human
H Cheng, D Shang, R Zhou - Signal transduction and targeted therapy, 2022 - nature.com
The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …
survival of mankind. The germline stem cells, as a unique cell type, generate various states …
Integrated molecular characterization of testicular germ cell tumors
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …
Testicular cancer biomarkers: a role for precision medicine in testicular cancer
R Leão, AE Ahmad, RJ Hamilton - Clinical genitourinary cancer, 2019 - Elsevier
Testicular germ cell tumors (TGCTs) represent the most common solid tumors among men
aged 15 to 34 years. Fortunately, recent advances have made testicular cancer a highly …
aged 15 to 34 years. Fortunately, recent advances have made testicular cancer a highly …
MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors
Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have
synergistic roles in cellular systems and their disruption may cause diseases including …
synergistic roles in cellular systems and their disruption may cause diseases including …
[HTML][HTML] Mechanisms of cisplatin sensitivity and resistance in testicular germ cell tumors
Testicular germ cell tumors (TGCTs) are a cancer pharmacology success story with a
majority of patients cured even in the highly advanced and metastatic setting. Successful …
majority of patients cured even in the highly advanced and metastatic setting. Successful …
Association of inherited pathogenic variants in checkpoint kinase 2 (CHEK2) with susceptibility to testicular germ cell tumors
Importance Approximately 50% of the risk for the development of testicular germ cell tumors
(TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet …
(TGCTs) is estimated to be heritable, but no mendelian TGCT predisposition genes have yet …
Testicular tumors: a contemporary update on morphologic, immunohistochemical and molecular features
KI Al-Obaidy, MT Idrees - Advances in anatomic pathology, 2021 - journals.lww.com
Testicular tumors are incredibly diverse and one of the most challenging areas in surgical
pathology. Because of the rarity and overlapping features with numerous entities occurring …
pathology. Because of the rarity and overlapping features with numerous entities occurring …
Large-scale sequencing of testicular germ cell tumour (TGCT) cases excludes major TGCT predisposition gene
Testicular germ cell tumour (TGCT), the most common cancer in young men, has a
significant heritable basis that has long raised questions as to the existence of underlying …
significant heritable basis that has long raised questions as to the existence of underlying …
Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression, and drug response
Insights into oncogenesis derived from cancer susceptibility loci (SNP) hold the potential to
facilitate better cancer management and treatment through precision oncology. However …
facilitate better cancer management and treatment through precision oncology. However …