The synthesis of the amide bond between an amine and a carboxylic acid is one of the most
significant reactions in industrial pharmaceutical synthesis. Despite the apparent simplicity …

Biocatalysis in nonaqueous media is becoming increasingly important in organic synthesis.
Lipases are the most used enzymes, especially in transesterification reactions. However, in …

The use of natural catalysts-enzymes-for the transformation of nonnatural man-made
organic compounds is not at all new: they have been used for more than one hundred years …

The lipase-catalyzed aminolysis of carboxylic esters is a fairly general reaction that has
been performed with a wide range of esters and amines, generally in anhydrous organic …

This chapter focuses on the principles of catalytic function of enzymes in monophasic
organic media, the consequences of removing bulk water from an enzymic reaction mixture …

Candida cylindracea lipase is a useful catalyst for the preparation of propiolamides.
Candida antarctica lipase efficiently catalyzes the aminolysis of different acrylic esters and …

A systematic study of the aminolysis of esters catalyzed by different lipases from different
origins was carried out. A factorial analysis showed that the main variables that control the …

An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and
3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach, an Ugi-4 …

Flash vacuum pyrolysis (FVP) of twelve acetylenic amides was investigated. Products of
pyrolysis were analyzed, characterized, and mechanisms for their thermal behavior were …

The lipase-catalysed reaction of aliphatic amine with ethyl propiolate was investigated using
benzylamine as reference amine. The conditions were optimised to favour the 1, 2-addition …