Dynamics and function of DNA methylation in plants
DNA methylation is a conserved epigenetic modification that is important for gene regulation
and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental …
and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental …
The histone variant H2A. Z in gene regulation
BD Giaimo, F Ferrante, A Herchenröther, SB Hake… - Epigenetics & …, 2019 - Springer
The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …
Histone exchange, chromatin structure and the regulation of transcription
S Venkatesh, JL Workman - Nature reviews Molecular cell biology, 2015 - nature.com
The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …
[HTML][HTML] Gene body methylation can alter gene expression and is a therapeutic target in cancer
DNA methylation in promoters is well known to silence genes and is the presumed
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
[HTML][HTML] Reversing DNA methylation: mechanisms, genomics, and biological functions
Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …
and is dynamically regulated during development. Compelling evidence now suggests that …
Functions of DNA methylation: islands, start sites, gene bodies and beyond
PA Jones - Nature reviews genetics, 2012 - nature.com
DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …
Gene body DNA methylation in plants
AJ Bewick, RJ Schmitz - Current opinion in plant biology, 2017 - Elsevier
Highlights•GbM is typified by mCG within coding regions, and depletion at the TSS and
TTS.•Species without gbM revealed an unexpected role for CMT3 in the evolution of …
TTS.•Species without gbM revealed an unexpected role for CMT3 in the evolution of …
[HTML][HTML] The Arabidopsis nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin
Nucleosome remodelers of the DDM1/Lsh family are required for DNA methylation of
transposable elements, but the reason for this is unknown. How DDM1 interacts with other …
transposable elements, but the reason for this is unknown. How DDM1 interacts with other …
Variants of core histones and their roles in cell fate decisions, development and cancer
M Buschbeck, SB Hake - Nature reviews Molecular cell biology, 2017 - nature.com
Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …
distribution that is regulated by specific deposition and removal machineries. These variants …
A double take on bivalent promoters
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …