Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …

Since the original descriptions of postconcussive pathophysiology, there has been a
significant increase in interest and ongoing research to study the biological underpinnings of …

Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis
of Alzheimer's disease (AD), and it is currently the primary therapeutic target in attempts to …

Traumatic brain injury (TBI) is an established risk factor for the early development of
dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits …

Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation
of the tau protein into filamentous inclusions that can be found in neurons and glial cells …

Axonal white matter injury is believed to be a major determinant of adverse outcomes
following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament …

Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …