Alterations of the balanced supply of the precursors of DNA synthesis, the
deoxyribonucleoside triphosphates, have dramatic genetic consequences for mammalian …

Correspondence: ILA. Bambara, Department of Biochemistry, Box 607, University of
Rochester Medical Center. 601 Elmwood Avenue, Rochester, NY 14642, USA and recent …

The action of 9-beta-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) on DNA synthesis was
evaluated both in whole cells and in vitro. 9-beta-D-Arabinofuranosyl-2-fluoroadenine was …

The action of 3'-azido-3'-deoxythymidine 5'-triphosphate (N3dTTP) on DNA strand
elongation catalyzed by human immunodeficiency virus type 1 reverse transcriptase was …

Agents discriminating between DNA polymerase alpha and DNA polymerases of class delta
(polymerase delta or epsilon) were used to characterize steps in the synthesis of the lagging …

DNA polymerase alpha, delta and epsilon can be isolated simultaneously from calf thymus.
DNA polymerase delta was purified to apparent homogeneity by a four-column procedure …

Inhibitory and substrate properties of analogs of deoxyribonucleoside triphosphates toward
DNA polymerases are reviewed. A general introduction is followed by a description of DNA …

Spontaneous mutations in somatic cells may engender several pathologic processes,
including cancer. The sources of these mutations remain to be established. We present a …

The structure of mutation in mammalian cells Page 1 Btochtmwa et Btophystca Acta, 1032 (1990)
1-17 1 Elsevter BBACAN 87218 The structure of mutation in mammalian cells Mark Meuth …

The mechanisms by which DNA polymerases achieve their remarkable fidelity, including
base selection and proofreading, are briefly reviewed. Nine proofreading models from the …