Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
[HTML][HTML] Unraveling hematopoiesis through the lens of genomics
LA Liggett, VG Sankaran - Cell, 2020 - cell.com
Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …
In the past decade, the genomics revolution has ushered in powerful new methods for …
[HTML][HTML] Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
A time-resolved, multi-symbol molecular recorder via sequential genome editing
DNA is naturally well suited to serve as a digital medium for in vivo molecular recording.
However, contemporary DNA-based memory devices are constrained in terms of the …
However, contemporary DNA-based memory devices are constrained in terms of the …
[HTML][HTML] Deciphering cell states and genealogies of human haematopoiesis
The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
INTRODUCTION Cancer progression is fundamentally an evolutionary process, involving
multiple distinct steps from oncogenic transformation to metastatic dissemination to …
multiple distinct steps from oncogenic transformation to metastatic dissemination to …
Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes
Complex gene regulatory mechanisms underlie differentiation and reprogramming.
Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA …
Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA …
Hotspot identifies informative gene modules across modalities of single-cell genomics
D DeTomaso, N Yosef - Cell systems, 2021 - cell.com
Two fundamental aims that emerge when analyzing single-cell RNA-seq data are identifying
which genes vary in an informative manner and determining how these genes organize into …
which genes vary in an informative manner and determining how these genes organize into …
Next-generation lineage tracing and fate mapping to interrogate development
Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …
Cellular barcoding to decipher clonal dynamics in disease
Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …