The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to
many neurological disorders, including stroke and Alzheimer's disease. How the basement …

Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD)
have revealed that muscle satellite stem cells play a direct role in contributing to disease …

Object Brain edema resulting from traumatic brain injury (TBI) or ischemia if uncontrolled
exhausts volume reserve and leads to raised intracranial pressure and brain herniation. The …

Cell transplantation offers a novel therapeutic strategy for stroke; however, how transplanted
cells function in vivo is poorly understood. We show for the first time that after subacute …

Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system,
particularly at the blood–brain and brain–cerebrospinal fluid barriers. Phenotype analysis of …

Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …