Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Cardiac function is controlled by the autonomic nervous system (ie, the sympathetic and the
parasympathetic nervous systems), which act via adrenoceptors and muscarinic …

Examples of G-protein-coupled receptors that can be biochemically detected in homo-or
heteromeric complexes are emerging at an accelerated rate. Biophysical approaches have …

Glucose enters the heart via GLUT1 and GLUT4 glucose transporters. GLUT4-deficient mice
develop striking cardiac hypertrophy and die prematurely. Whether their cardiac changes …

It has recently been recognized that cellular stresses activate certain members of the
mitogen-activated protein kinase (MAPK) superfamily. One role of these “stress-activated” …

Hypertrophy of myocytes in the heart ventricles is an important adaptation that in vivo occurs
in response to a requirement for increased contractile power. It involves changes at the level …

We showed before that in neonatal rat cardiac myocytes partial inhibition of Na+/K+-ATPase
by nontoxic concentrations of ouabain causes hypertrophic growth and transcriptional …

α1-Adrenoceptors are one of three subfamilies of receptors (α1, α2, β) mediating responses
to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …

Objective: Sympathetic nervous system activity in the myocardium is increased in patients
with heart failure. However, the in vivo mechanisms responsible for β-adrenoceptor …

Abstract β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac
function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker …