Understanding COVID-19-associated coagulopathy
EM Conway, N Mackman, RQ Warren… - Nature Reviews …, 2022 - nature.com
Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …
The state of complement in COVID-19
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
A guide to complement biology, pathology and therapeutic opportunity
DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
Immune response in COVID-19: what is next?
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches
J Ahamed, J Laurence - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
SARS-CoV-2–infected individuals may suffer a multi–organ system disorder known as “long
COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). There are no standard …
COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). There are no standard …
Patients with COVID-19: in the dark-NETs of neutrophils
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …
Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
P Skendros, A Mitsios… - The Journal of …, 2020 - Am Soc Clin Investig
Emerging data indicate that complement and neutrophils contribute to the maladaptive
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …
immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby …
COVID-19: A review of therapeutic strategies and vaccine candidates
The world is engulfed by one of the most widespread and significant public health crises in
decades as COVID-19 has become among the leading causes of death internationally. The …
decades as COVID-19 has become among the leading causes of death internationally. The …
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …