Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health

BP O'Gara, L Gao, ER Marcantonio… - Anesthesiology, 2021 - pubs.asahq.org
The prevention of perioperative neurocognitive disorders is a priority for patients, families,
clinicians, and researchers. Given the multiple risk factors present throughout the …

Circadian rhythms and astrocytes: the good, the bad, and the ugly

MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

[HTML][HTML] Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies

D Chan, HJ Suk, BL Jackson, NP Milman, D Stark… - PloS one, 2022 - journals.plos.org
Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz reduces
Alzheimer's disease (AD) pathology such as amyloid and tau levels, prevents cerebral …

[PDF][PDF] Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer's disease

DS Whittaker, L Akhmetova, D Carlin, H Romero… - Cell Metabolism, 2023 - cell.com
Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …

[HTML][HTML] Circadian disruption and sleep disorders in neurodegeneration

Y Shen, Q Lv, W Xie, S Gong, S Zhuang, J Liu… - Translational …, 2023 - Springer
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

Association of 24-hour activity pattern phenotypes with depression symptoms and cognitive performance in aging

SF Smagula, G Zhang, S Gujral, N Covassin… - JAMA …, 2022 - jamanetwork.com
Importance Evidence regarding the nature and prevalence of 24-hour activity pattern
phenotypes in older adults, especially those related to depression symptoms and cognition …

Daytime napping and Alzheimer's dementia: A potential bidirectional relationship

P Li, L Gao, L Yu, X Zheng, MC Ulsa… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Daytime napping is frequently seen in older adults. The longitudinal relationship
between daytime napping and cognitive aging is unknown. Methods Using data from 1401 …

Circadian Rest–Activity Rhythms, Delirium Risk, and Progression to Dementia

L Gao, P Li, N Gaykova, X Zheng, C Gao… - Annals of …, 2023 - Wiley Online Library
Objective Delirium is a complex neurocognitive syndrome suspected to be bidirectionally
linked to dementia. Circadian rhythm disturbances likely contribute to dementia …

[HTML][HTML] Circadian and sleep dysfunctions in neurodegenerative disorders—An update

K Fifel, A Videnovic - Frontiers in Neuroscience, 2021 - frontiersin.org
Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered …

[HTML][HTML] Association of circadian rhythms with brain disorder incidents: a prospective cohort study of 72242 participants

SJ Chen, YT Deng, YZ Li, YR Zhang, W Zhang… - Translational …, 2022 - nature.com
Circadian rhythm disruption (CRD) is a shared characteristic of various brain disorders, such
as Alzheimer's disease (AD), Parkinson's disease (PD), and major depression disorder …