CRISPR-Cas9 is widely used in genomic editing, but the kinetics of target search and its
relation to the cellular concentration of Cas9 have remained elusive. Effective target search …

In many technological applications, DNA is confined within nanoenvironments that are
smaller than the size of the unconfined polymer in solution. However, the dependence of the …

Biophysical Reviews ‘Meet the Editors Series’ — a profile of Sabrina Leslie | Biophysical
Reviews Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Confining DNA molecules with high throughput and structural integrity is an important
challenge in nanochannel-based genomic mapping technology. Here we demonstrate …

Strongly confined environments (confined dimensions between 1–100 nm) represent unique
challenges and opportunities for understanding and manipulating molecular behavior due to …

Super-resolution microscopy is frequently employed in the life sciences, but the number of
freely accessible and affordable microscopy frameworks, especially for single particle …

The objective of this work was to explore the dynamics of polymers within various types of
confined environments at the solid-aqueous interface by leveraging high-throughput single …

As biological physics develops at the level of single-molecule studies, new tools are
required to make observations at micrometer and nanometer scales. Many methods have …

My masters' research has been devoted to the design, development, and characterization of
new instrumentation hardware for the Leslie biophysics lab. The first instruments I present in …