Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease
Streptococcus pneumoniae (the pneumococcus) is a common colonizer of the human
nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization …
nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization …
Next generation pneumococcal vaccines
KL Moffitt, R Malley - Current opinion in immunology, 2011 - Elsevier
Currently licensed pneumococcal vaccines are based on the generation of antibodies to the
pneumococcal polysaccharide, of which there are more than 90 different types. While these …
pneumococcal polysaccharide, of which there are more than 90 different types. While these …
Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and Colonization In Vitro and In Vivo
LR Marks, GI Parameswaran… - Infection and …, 2012 - Am Soc Microbiol
The human nasopharynx is the main reservoir for Streptococcus pneumoniae (the
pneumococcus) and the source for both horizontal spread and transition to infection. Some …
pneumococcus) and the source for both horizontal spread and transition to infection. Some …
Polyamine biosynthesis and transport mechanisms are crucial for fitness and pathogenesis of Streptococcus pneumoniae
Polyamines such as cadaverine, putrescine and spermidine are polycationic molecules that
have pleiotropic effects on cells via their interaction with nucleic acids. Streptococcus …
have pleiotropic effects on cells via their interaction with nucleic acids. Streptococcus …
The long search for a serotype independent pneumococcal vaccine
Introduction: Serotype replacement–a consequence of polysaccharide vaccine use–will
continue to drive the inclusion of new serotypes on conjugate vaccines, increasing …
continue to drive the inclusion of new serotypes on conjugate vaccines, increasing …
MetQ of Neisseria gonorrhoeae is a surface-expressed antigen that elicits bactericidal and functional blocking antibodies
Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI)
gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We …
gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We …
The Effects of Methionine Acquisition and Synthesis on Streptococcus Pneumoniae Growth and Virulence
Bacterial pathogens need to acquire nutrients from the host, but for many nutrients their
importance during infection remain poorly understood. We have investigated the importance …
importance during infection remain poorly understood. We have investigated the importance …
Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins
Histatin 5 (Hst 5) is a salivary gland-secreted cationic peptide with potent fungicidal activity
against Candida albicans. Hst 5 kills fungal cells following intracellular translocation …
against Candida albicans. Hst 5 kills fungal cells following intracellular translocation …
Polyamine Synthesis Effects Capsule Expression by Reduction of Precursors in Streptococcus pneumoniae
MB Ayoola, LA Shack, MF Nakamya… - Frontiers in …, 2019 - frontiersin.org
Streptococcus pneumoniae (pneumococcus, Spn) colonizes the human nasopharynx
asymptomatically but can cause infections such as otitis media, and invasive pneumococcal …
asymptomatically but can cause infections such as otitis media, and invasive pneumococcal …
Fusobacterium nucleatum Envelope Protein FomA Is Immunogenic and Binds to the Salivary Statherin-Derived Peptide
H Nakagaki, S Sekine, Y Terao, M Toe… - Infection and …, 2010 - Am Soc Microbiol
We have previously shown that one of the minimal active regions of statherin, a human
salivary protein, for binding to Fusobacterium nucleatum is a YQPVPE amino acid …
salivary protein, for binding to Fusobacterium nucleatum is a YQPVPE amino acid …