Poly (A) tails are non-templated additions of adenosines at the 3′ ends of most eukaryotic
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

Integrator regulates the 3′-end processing and termination of multiple classes of
noncoding RNAs. Depletion of INTS11, the catalytic subunit of Integrator, or ectopic …

Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …

In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …

Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA
processing that involves usage of more than one polyadenylation site (PA‐site) generating …

In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies
have suggested that polyadenylate tail may play a vital role in such a system. The poly (A) …

RNA binding motif protein 10 (RBM10) is a regulator of alternative splicing in apoptosis and
inflammation. We discovered a splicing-independent function of RBM10 critical for the …

Mammalian oocyte maturation is driven by strictly regulated polyadenylation and
translational activation of maternal mRNA stored in the cytoplasm. However, the poly (A) …

Viruses have evolved diverse strategies to hijack the cellular gene expression system for
their replication. The poly (A) binding proteins (PABPs), a family of critical gene expression …