Tales of detailed poly (A) tails
AL Nicholson, AE Pasquinelli - Trends in cell biology, 2019 - cell.com
Poly (A) tails are non-templated additions of adenosines at the 3′ ends of most eukaryotic
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …
mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly (A) site and …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
Integrator enforces the fidelity of transcriptional termination at protein-coding genes
LF Dasilva, E Blumenthal, F Beckedorff… - Science …, 2021 - science.org
Integrator regulates the 3′-end processing and termination of multiple classes of
noncoding RNAs. Depletion of INTS11, the catalytic subunit of Integrator, or ectopic …
noncoding RNAs. Depletion of INTS11, the catalytic subunit of Integrator, or ectopic …
Spatiotemporal regulation of maternal mRNAs during vertebrate oocyte meiotic maturation
Y Jiang, D Adhikari, C Li, X Zhou - Biological Reviews, 2023 - Wiley Online Library
Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …
Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism
Z Warkocki, V Liudkovska… - … of the Royal …, 2018 - royalsocietypublishing.org
In eukaryotes, almost all RNA species are processed at their 3′ ends and most mRNAs are
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …
polyadenylated in the nucleus by canonical poly (A) polymerases. In recent years, several …
Alternative polyadenylation: An enigma of transcript length variation in health and disease
NK Mohanan, F Shaji, GR Koshre… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Alternative polyadenylation (APA) is a molecular mechanism during a pre‐mRNA
processing that involves usage of more than one polyadenylation site (PA‐site) generating …
processing that involves usage of more than one polyadenylation site (PA‐site) generating …
The dynamic poly (A) tail acts as a signal hub in mRNA metabolism
G Zhang, H Luo, X Li, Z Hu, Q Wang - Cells, 2023 - mdpi.com
In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies
have suggested that polyadenylate tail may play a vital role in such a system. The poly (A) …
have suggested that polyadenylate tail may play a vital role in such a system. The poly (A) …
A splicing-independent function of RBM10 controls specific 3′ UTR processing to regulate cardiac hypertrophy
RNA binding motif protein 10 (RBM10) is a regulator of alternative splicing in apoptosis and
inflammation. We discovered a splicing-independent function of RBM10 critical for the …
inflammation. We discovered a splicing-independent function of RBM10 critical for the …
Oocyte meiosis-coupled poly (A) polymerase α phosphorylation and activation trigger maternal mRNA translation in mice
JC Jiang, H Zhang, LR Cao, XX Dai… - Nucleic acids …, 2021 - academic.oup.com
Mammalian oocyte maturation is driven by strictly regulated polyadenylation and
translational activation of maternal mRNA stored in the cytoplasm. However, the poly (A) …
translational activation of maternal mRNA stored in the cytoplasm. However, the poly (A) …
When Poly (A) binding proteins meet viral infections, including SARS-CoV-2
J Gao, YD Tang, W Hu, C Zheng - Journal of Virology, 2022 - Am Soc Microbiol
Viruses have evolved diverse strategies to hijack the cellular gene expression system for
their replication. The poly (A) binding proteins (PABPs), a family of critical gene expression …
their replication. The poly (A) binding proteins (PABPs), a family of critical gene expression …