Genome-wide panels of SNPs have recently been used in domestic animal species to map
and identify genes for many traits and to select genetically desirable livestock. This has led …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Age-related neurodegenerative diseases are largely limited to humans and rarely occur
spontaneously in animals. Genetically engineered mouse models recapitulate aspects of the …

Abstract Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in
adults. Classical ALS is characterized by the death of upper and lower motor neurons …

Evidence of intervertebral disk degeneration (IVDD) is extremely common in dogs, and its
prevalence increases with age. It has many important consequences because degeneration …

Studies to evaluate the therapeutic potential of stem cells in humans would benefit from
more realistic animal models. In veterinary medicine, companion animals naturally develop …

To date, 146 different mutations in superoxide dismutase 1 (SOD1) have been identified in
patients with familial amyotrophic lateral sclerosis (ALS). The mean age of disease onset in …

The last 30 years have seen a major advance in the understanding of the clinical and
pathological heterogeneity of amyotrophic lateral sclerosis (ALS), and its overlap with …

Breed Predispositions to Disease in Dogs and Cats, Third Edition provides a comprehensive
exploration of current knowledge of breed predispositions based on rigorous examination of …

In recent years Canis familiaris, the domestic dog, has drawn considerable attention as a
system in which to investigate the genetics of disease susceptibility, morphology and …