[HTML][HTML] A mini review on osteoporosis: from biology to pharmacological management of bone loss

KY Chin, BN Ng, MKI Rostam… - Journal of Clinical …, 2022 - mdpi.com
Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …

Novel insights into the complex architecture of osteoporosis molecular genetics

FA Saad - Annals of the New York Academy of Sciences, 2020 - Wiley Online Library
Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease
in bone mass and decline of bone microarchitecture, due to impaired bone matrix …

[HTML][HTML] The relationship between follicle-stimulating hormone and bone health: Alternative explanation for bone loss beyond oestrogen?

KY Chin - International journal of medical sciences, 2018 - ncbi.nlm.nih.gov
Bone loss in women commences before the onset of menopause and oestrogen deficiency.
The increase of follicle-stimulating hormone (FSH) precedes oestrogen decline and may be …

[HTML][HTML] The role of tocotrienol in preventing male osteoporosis—A review of current evidence

KY Chin, S Ima-Nirwana - International journal of molecular sciences, 2019 - mdpi.com
Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a
higher mortality rate post-fracture than women and they are marginalized in osteoporosis …

Combination radium-223 therapies in patients with bone metastases from castration-resistant prostate cancer: A review

MC Cursano, M Iuliani, C Casadei, M Stellato… - Critical reviews in …, 2020 - Elsevier
Abstract Chemotherapeutic agents (docetaxel, cabazitaxel), hormonal therapies
(abiraterone, enzalutamide) and radium-223 improve survival in patients with bone …

[HTML][HTML] Knockdown of GSG2 inhibits prostate cancer progression in vitro and in vivo

F Yu, Y Lin, X Xu, W Liu, D Tang… - International …, 2020 - spandidos-publications.com
Prostate cancer (PCa) is the second leading cause of cancer‑related death among men
worldwide. The present study aimed to investigate the role of germ cell‑specific gene 2 …

[HTML][HTML] The use of selective estrogen receptor modulators on bone health in men

SK Wong, NV Mohamad, PA Jayusman, AN Shuid… - The Aging …, 2019 - Taylor & Francis
Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as
agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs …

Nursing considerations for androgen deprivation therapy and bone health in men affected by prostate cancer

DG Cope - Seminars in Oncology Nursing, 2022 - Elsevier
Objective This article reviews the effects of androgen deprivation therapy on bone health
and loss of bone mineral density and its effects on risk of fractures for men with prostate …

[HTML][HTML] Establishing an animal model of secondary osteoporosis by using a gonadotropin-releasing hormone agonist

NV Mohamad, MAAC Zulkepli… - … Journal of Medical …, 2018 - ncbi.nlm.nih.gov
Introduction: Orchidectomy is currently the preferred method to induce bone loss in
preclinical male osteoporosis model. Gonadotropin-releasing hormone (GnRH) agonists …

An exploratory first‐in‐man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2‐and 1‐week interval in patients with metastatic …

JPM Vrouwe, IMC Kamerling… - Pharmacology …, 2021 - Wiley Online Library
Dexamethasone has antitumor activity in metastatic castration resistant prostate cancer
(mCRPC). We aimed to investigate intravenous liposome‐encapsulated dexamethasone …