Effects of shear stress on endothelial cells: go with the flow
DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2017 - Wiley Online Library
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …
Macrophage‐mediated cholesterol handling in atherosclerosis
DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2016 - Wiley Online Library
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …
[HTML][HTML] Macrophages in the pathogenesis of atherosclerosis
In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
[HTML][HTML] Heme oxygenase-1, oxidation, inflammation, and atherosclerosis
JA Araujo, M Zhang, F Yin - Frontiers in pharmacology, 2012 - frontiersin.org
Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …
Monocyte and macrophage dynamics during atherogenesis
Vascular inflammation is associated with and in large part driven by changes in the
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …
Cytokines in atherosclerosis: pathogenic and regulatory pathways
A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
Chronic inflammation drives the development of atherosclerosis, and details regarding the
involvement of different leukocyte subpopulations in the pathology of this disease have …
involvement of different leukocyte subpopulations in the pathology of this disease have …
Inflammation and immune system interactions in atherosclerosis
B Legein, L Temmerman, EAL Biessen… - Cellular and Molecular …, 2013 - Springer
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for
16.7 million deaths each year. The underlying cause of the majority of CVD is …
16.7 million deaths each year. The underlying cause of the majority of CVD is …
Monocyte recruitment and foam cell formation in atherosclerosis
YV Bobryshev - Micron, 2006 - Elsevier
Atherosclerosis is a chronic immune-inflammatory disease in which the interactions of
monocytes with activated endothelium are crucial events leading to atherosclerotic alteration …
monocytes with activated endothelium are crucial events leading to atherosclerotic alteration …