Effects of shear stress on endothelial cells: go with the flow

DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2017 - Wiley Online Library
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Macrophage‐mediated cholesterol handling in atherosclerosis

DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2016 - Wiley Online Library
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

[HTML][HTML] Macrophages in the pathogenesis of atherosclerosis

KJ Moore, I Tabas - Cell, 2011 - cell.com
In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

[HTML][HTML] Heme oxygenase-1, oxidation, inflammation, and atherosclerosis

JA Araujo, M Zhang, F Yin - Frontiers in pharmacology, 2012 - frontiersin.org
Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Monocyte and macrophage dynamics during atherogenesis

K Ley, YI Miller, CC Hedrick - Arteriosclerosis, thrombosis, and …, 2011 - Am Heart Assoc
Vascular inflammation is associated with and in large part driven by changes in the
leukocyte compartment of the vessel wall. Here, we focus on monocyte influx during …

Cytokines in atherosclerosis: pathogenic and regulatory pathways

A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

C Weber, A Zernecke, P Libby - Nature reviews immunology, 2008 - nature.com
Chronic inflammation drives the development of atherosclerosis, and details regarding the
involvement of different leukocyte subpopulations in the pathology of this disease have …

Inflammation and immune system interactions in atherosclerosis

B Legein, L Temmerman, EAL Biessen… - Cellular and Molecular …, 2013 - Springer
Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for
16.7 million deaths each year. The underlying cause of the majority of CVD is …

Monocyte recruitment and foam cell formation in atherosclerosis

YV Bobryshev - Micron, 2006 - Elsevier
Atherosclerosis is a chronic immune-inflammatory disease in which the interactions of
monocytes with activated endothelium are crucial events leading to atherosclerotic alteration …