Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases

Y Wan, J Xia, J Xu, L Chen, Y Yang, JJ Wu… - Pharmacological …, 2022 - Elsevier
Obesity, is an increasingly global public health problem associated complications. However,
the proven anti-obesity agents are inefficient with adverse side effects; hence attention is …

[HTML][HTML] Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

T Zhao, Y Zhu, R Zhao, S Xiong, J Sun, J Zhang… - Pharmacological …, 2023 - Elsevier
Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial
to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and …

Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats

Y Wang, W Yao, B Li, S Qian, B Wei, S Gong… - … & molecular medicine, 2020 - nature.com
Gut microbiota dysbiosis has a significant role in the pathogenesis of metabolic diseases,
including obesity. Nuciferine (NUC) is a main bioactive component in the lotus leaf that has …

Nuciferine ameliorates hepatic steatosis in high‐fat diet/streptozocin‐induced diabetic mice through a PPARα/PPARγ coactivator‐1α pathway

C Zhang, J Deng, D Liu, X Tuo, L Xiao… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Nuciferine, an alkaloid found in Nelumbo nucifera leaves,
alleviates dyslipidemia in vivo. However, whether it improves liver injury in diabetic …

Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats

J Sun, J Fan, T Li, X Yan, Y Jiang - Journal of Agricultural and …, 2022 - ACS Publications
Our previous study showed that nuciferine (NF) attenuated non-alcoholic fatty liver disease
(NAFLD), which is attributed to a high-fat diet (HFD) through reinforcing intestinal barrier …

[HTML][HTML] Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia

Y Yu, J Lu, L Sun, X Lyu, X Chang, X Mi, M Hu… - Biomedicine & …, 2021 - Elsevier
Background Intestinal microbiota is a novel drug target of metabolic diseases, especially for
those with poor oral bioavailability. Nuciferine, with poor bioavailability, has an anti …

Research advances in traditional and modern use of Nelumbo nucifera: phytochemicals, health promoting activities and beyond

G Chen, M Zhu, M Guo - Critical reviews in food science and …, 2019 - Taylor & Francis
Nelumbo nucifera, or sacred lotus, has been valuable for us to use as vegetable, functional
food, and herb medicine for over 2,000 years. The purpose of this article is to systematically …

Nuciferine inhibits TMEM16A in dietary adjuvant therapy for lung cancer

X Bai, X Liu, S Li, H An, X Kang… - Journal of agricultural and …, 2022 - ACS Publications
Lung cancer is a malignant tumor with the highest morbidity and mortality rates. Food
therapy is a common adjuvant treatment for lung cancer due to its safety and painlessness …

Lotus (Nelumbo nucifera Gaertn.) leaf: A narrative review of its Phytoconstituents, health benefits and food industry applications

Z Wang, Y Cheng, M Zeng, Z Wang, F Qin… - Trends in Food Science …, 2021 - Elsevier
Abstract Background Lotus (Nelumbo nucifera Gaertn.) is a water plant belonging to the
family Nelumbonacea that is cultivated in many areas of the world, and it is mainly …

Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice

MX Wang, YL Liu, Y Yang, DM Zhang… - European Journal of …, 2015 - Elsevier
Nuciferine, a major aporphine alkaloid of the leaves of Nelumbo nucifera, was found to
decrease serum urate levels and improved kidney function, as well as inhibited system and …