For many years immunologists have been well served by the viewpoint that the immune
system's primary goal is to discriminate between self and non-self. I believe that it is time to …

Technological advances in recent years have allowed for an ever-expanding ability to
analyze and quantify in vivo immune responses. MHC tetramers, intracellular cytokine …

We examined the regulation of virus-specific CD8 T cell responses during chronic
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of
dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is …

A long-standing paradox in cellular immunology concerns the conditional requirement for
CD4+ T-helper (TH) cells in the priming of cytotoxic CD8+ T lymphocyte (CTL) responses in …

Pathogen-associated molecular patterns decisively influence antiviral immune responses,
whereas the contribution of endogenous signals of tissue damage, also known as damage …

Although primary CD8 responses to acute infections are independent of CD4 help, it is
unknown whether a similar situation applies to secondary responses. We show that …

Interferon-γ (IFN-γ) exerts pleiotropic effects, including antiviral activity, stimulation of
macrophages and natural killer cells, and increased expression of major histocompatibility …

The induction of optimal systemic antitumor immunity involves the priming of both CD4+ and
CD8+ T cells specific for tumor-associated antigens. The role of CD4+ T helper cells (Th) in …

In this study, we have examined the relative contributions of CD4+ and CD8+ T cells in
controlling an acute or chronic lymphocytic choriomeningitis virus (LCMV) infection. To study …