Bioactive compounds derived from herbal medicinal plants modulate various therapeutic
targets and signaling pathways associated with cardiovascular diseases (CVDs), the world's …

Fungal pathogens undergo specific morphogenetic transitions in order to breach the outer
surfaces of plants and invade the underlying host tissue. The ability to change cell shape …

Blood endothelial cells control the hemostatic and inflammatory response by secreting von
Willebrand factor (VWF) and P-selectin from storage organelles called Weibel-Palade …

Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …

Blood vessel endothelial cells (EC) display heterogeneity across vascular beds, which is
anticipated to drive site-specific vascular pathology. This heterogeneity is assessed using …

Weibel Palade bodies (WPB) are lysosome‐related secretory organelles of endothelial cells.
Commonly known for their main cargo, the platelet and leukocyte receptors von‐Willebrand …

The kinome includes over 500 different protein kinases, which form an integrated kinase
network that regulates cellular phosphorylation signals. The kinome plays a central role in …

Venous thromboembolic disease (VTE) is a prevalent and potentially life-threatening
vascular disease including both deep vein thrombosis and pulmonary embolism. This …

In this issue of Blood Advances, El-Mansi et al 1 communicate a novel mechanism important
in the context of hemostasis and thrombosis related to the role of myosin 1C (Myo1c) in von …

WPBs are endothelial cell–specific secretory organelles that, together with a long list of
inflammatory and angiogenic mediators, store the hemostatic protein von Willebrand factor …