Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …

The organization of metabolic multienzyme complexes has been hypothesized to benefit
metabolic processes and provide a coordinated way for the cell to regulate metabolism …

Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-
limiting step in fatty acid biosynthesis,. Eukaryotic acetyl-CoA carboxylases are large …

The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence
lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on …

Highlights•Novel orthogonal and reversible CID systems confer multiple layers of
manipulation.•Caged dimerizers allow control of protein function with spatiotemporal …

The arrangement of proteins into complexes is a key organizational principle for many
cellular functions. Although the topology of many complexes has been systematically …

Metabolism is the sum of the life-giving chemical processes that occur within a cell. Proper
regulation of these processes is essential for all organisms to thrive and prosper. When …

Compartmentation via filamentation has recently emerged as a novel mechanism for
metabolic regulation. In order to identify filament-forming metabolic enzymes systematically …

26S proteasome abundance is tightly regulated at multiple levels, including the elimination
of excess or inactive particles by autophagy. In yeast, this proteaphagy occurs upon nitrogen …

To grow and divide, cells must extract resources from dynamic and unpredictable
environments. Many organisms use different metabolic strategies for distinct contexts …