Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

With the opioid crisis in North America, opioid addiction has come in the spotlight and
reveals the weakness of the current treatments. Two main opioid substitution therapies …

Opioids play a pivotal role in managing chronic pain with increasing prescription rates over
the last few years. Hence, it is crucial to focus on the adverse effects of narcotics, and one of …

Introduction Methadone has long been regarded as an effective treatment for opioid
dependence. However, many patients discontinue maintenance therapy because of its side …

Abstract: A variety of studies evidenced a relationship between drug use disorders and
sexual dysfunction. In particular, heroin and opioid agonist medications to treat heroin …

Novel synthetic opioids (NSO) are an emerging class belonging to new psychoactive
substances (NPS). They include fentanyl (eg, acetylfentanyl, ocfentanil, carfentanil …

Opioids are pivotal therapeutics in the management of escalated chronic pain (moderate–
severe). In the last two decades, the increased prescription rate and the prolonged usage of …

Context Hypogonadism is a well-established consequence of opioid use. It has been
reported in both men and women, although more widely studied in men. Evidence …

BACKGROUND: Spinal Cord Injury (SCI) causes neurological impairment with resultant
neurogenic sexual dysfunction which can compound preexisting psychological and medical …

Methadone is largely recognized as an effective treatment for opiate-dependent patients;
however, it causes reduced brain dopaminergic action resulting in significant sexual …