Argonaute proteins are conserved throughout all domains of life. Recently characterized
prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference …

Epigenetics involves the heritable changes in patterns of gene expression determined by
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …

RNA interference (RNAi) pathways are widespread in metaozoans but the genes required
show variable occurrence or activity in eukaryotic microbes, including many pathogens …

Background The transition from prokaryotes to eukaryotes was the most radical change in
cell organisation since life began, with the largest ever burst of gene duplication and novelty …

The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic
cells are poorly understood compared to well-studied model systems involving obligate …

Protozoan parasites that profoundly affect mankind represent an exceptionally diverse group
of organisms, including Plasmodium, Toxoplasma, Entamoeba, Giardia, trypanosomes, and …

Algae are a large group of aquatic, typically photosynthetic, eukaryotes that include species
from very diverse phylogenetic lineages, from those similar to land plants to those related to …

RNA is targeted in biological conflicts by enzymatic toxins or effectors. A vast diversity of
systems which repair or 'heal'this damage has only recently become apparent. Here, we …

Faithful transmission of genetic material is essential for the survival of all organisms.
Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto …

The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis
encodes one of the largest known proteome with 60,000 candidate proteins. This provides …