[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
[HTML][HTML] Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC)
mutational signature has only recently been detected in a multitude of cancers through next …
mutational signature has only recently been detected in a multitude of cancers through next …
Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer
Ionizing radiation causes DNA damage and is a mainstay for cancer treatment, but
understanding of its genomic impact is limited. We analyzed mutational spectra following …
understanding of its genomic impact is limited. We analyzed mutational spectra following …
Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
K Shi, MA Carpenter, S Banerjee, NM Shaban… - Nature structural & …, 2017 - nature.com
APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …
[HTML][HTML] APOBEC enzymes as targets for virus and cancer therapy
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
The APOBEC3 family of retroelement restriction factors
EW Refsland, RS Harris - Intrinsic immunity, 2013 - Springer
The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …
Medicinal chemistry strategies toward host targeting antiviral agents
X Ji, Z Li - Medicinal Research Reviews, 2020 - Wiley Online Library
Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and
have been demonstrated to be very successful in combating viral infections in clinic …
have been demonstrated to be very successful in combating viral infections in clinic …
[HTML][HTML] Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
T Kouno, TV Silvas, BJ Hilbert, SMD Shandilya… - Nature …, 2017 - nature.com
Nucleic acid editing enzymes are essential components of the immune system that lethally
mutate viral pathogens and somatically mutate immunoglobulins, and contribute to the …
mutate viral pathogens and somatically mutate immunoglobulins, and contribute to the …
[HTML][HTML] APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
K Butler, AR Banday - Journal of Hematology & Oncology, 2023 - Springer
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …
deaminases involved in innate and adaptive immunity. However, some APOBEC family …
[HTML][HTML] Elevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers
AM Sieuwerts, S Willis, MB Burns, MP Look… - Hormones and …, 2014 - Springer
Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic
evolution of breast cancer. We addressed whether APOBEC3B is associated with breast …
evolution of breast cancer. We addressed whether APOBEC3B is associated with breast …