Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Integrins are transmembrane receptors that coordinate extracellular matrix (ECM)–cell and
cell–cell interactions, signal transmission, gene expression, and cell function. The aberration …

Cancer is a disease of altered signaling and metabolism, causing uncontrolled division and
survival of transformed cells. A host of molecules, factors, and conditions have been …

Cell invasion through the basement membrane (BM) occurs during normal embryonic
development and is a fundamental feature of cancer metastasis. The underlying cellular and …

The transcription factor SOX11 (SRY-related high-mobility-group (HMG) box 11), a member
of the SOXC group, is expressed during embryogenesis but largely absent in most adult …

Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell
proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a …

Overlapping principles of embryonic and tumor biology have been described, with recent
multi-omics campaigns uncovering shared molecular profiles between human pluripotent …

Intravascular dissemination of tumor cells is the accepted mechanism of cancer metastasis.
However, the phenomenon of angiotropism, pericyte mimicry (PM), and extravascular …

Oncogenic pathways that drive cancer progression reflect both genetic changes and
epigenetic regulation. Here we stratified primary tumors from each of 24 TCGA adult cancer …