Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Latest developments in metal complexes as anticancer agents

R Paprocka, M Wiese-Szadkowska… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …

Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S Jin, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium

CC Konkankit, SC Marker, KM Knopf, JJ Wilson - Dalton Transactions, 2018 - pubs.rsc.org
The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Organometallic and coordination rhenium compounds and their potential in cancer therapy

EB Bauer, AA Haase, RM Reich, DC Crans… - Coordination Chemistry …, 2019 - Elsevier
This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of
action in biological systems and their status in clinical trials. Biological studies of different …

Metal coordination complexes as therapeutic agents for ischemia-reperfusion injury

NP Bigham, JJ Wilson - Journal of the American Chemical Society, 2023 - ACS Publications
Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …

Anticancer and antibiotic rhenium tri-and dicarbonyl complexes: current research and future perspectives

K Schindler, F Zobi - Molecules, 2022 - mdpi.com
Organometallic compounds are increasingly recognized as promising anticancer and
antibiotic drug candidates. Among the transition metal ions investigated for these purposes …

Recent development of rhenium-based materials in the application of diagnosis and tumor therapy

Q Qi, Q Wang, Y Li, DZ Silva, MEL Ruiz, R Ouyang… - Molecules, 2023 - mdpi.com
Rhenium (Re) is widely used in the diagnosis and treatment of cancer due to its unique
physical and chemical properties. Re has more valence electrons in its outer shell, allowing …

Metal-based antitumor compounds: Beyond cisplatin

PV Simpson, NM Desai, I Casari, M Massi… - Future Medicinal …, 2019 - Taylor & Francis
Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin
lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain …

On the preferences of five-membered chelate rings in coordination chemistry: insights from the Cambridge Structural Database and theoretical calculations

M Bazargan, M Mirzaei, A Franconetti… - Dalton Transactions, 2019 - pubs.rsc.org
The purpose of this review is to give an overview of three important N-bidentate ligands: 1,
10-phenanthroline (phen), 2, 2′-bipyridine (bpy), and ethylenediamine (en). We have not …