Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system
S Gritsch, TT Batchelor, LN Gonzalez Castro - Cancer, 2022 - Wiley Online Library
The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …
central nervous system (CNS) tumors incorporated molecular features with histologic …
cIMPACT‐NOW update 7: advancing the molecular classification of ependymal tumors
DW Ellison, KD Aldape, D Capper, M Fouladi… - Brain …, 2020 - Wiley Online Library
Advances in our understanding of the biological basis and molecular characteristics of
ependymal tumors since the latest iteration of the World Health Organization (WHO) …
ependymal tumors since the latest iteration of the World Health Organization (WHO) …
cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading
Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …
[PDF][PDF] Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus
B Ho, PD Johann, Y Grabovska… - Neuro …, 2020 - academic.oup.com
Background Atypical teratoid/rhabdoid tumors (ATRTs) are known to exhibit molecular and
clinical heterogeneity even though SMARCB1 inactivation is the sole recurrent genetic event …
clinical heterogeneity even though SMARCB1 inactivation is the sole recurrent genetic event …
[HTML][HTML] Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma
Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …
Ependymoma: evaluation and management updates
R Rudà, F Bruno, A Pellerino, R Soffietti - Current Oncology Reports, 2022 - Springer
Abstract Purpose of Review To review state of art and relevant advances in the molecular
genetics and management of ependymomas of children and adults. Recent Findings …
genetics and management of ependymomas of children and adults. Recent Findings …
The genomic landscape of pediatric cancers: Implications for diagnosis and treatment
EA Sweet-Cordero, JA Biegel - Science, 2019 - science.org
The past decade has witnessed a major increase in our understanding of the genetic
underpinnings of childhood cancer. Genomic sequencing studies have highlighted key …
underpinnings of childhood cancer. Genomic sequencing studies have highlighted key …
The biology of ependymomas and emerging novel therapies
Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …
Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q
LV Baroni, L Sundaresan, A Heled, H Coltin… - Neuro …, 2021 - academic.oup.com
Abstract Background Within PF-EPN-A, 1q gain is a marker of poor prognosis, however, it is
unclear if within PF-EPN-A additional cytogenetic events exist which can refine risk …
unclear if within PF-EPN-A additional cytogenetic events exist which can refine risk …
DNA methylation profiling as a model for discovery and precision diagnostics in neuro-oncology
Recent years have witnessed a shift to more objective and biologically-driven methods for
central nervous system (CNS) tumor classification. The 2016 world health organization …
central nervous system (CNS) tumor classification. The 2016 world health organization …