[HTML][HTML] Synergistic effects of plant derivatives and conventional chemotherapeutic agents: an update on the cancer perspective

R Pezzani, B Salehi, S Vitalini, M Iriti, FA Zuñiga… - Medicina, 2019 - mdpi.com
Synergy is a process in which some substances cooperate to reach a combined effect that is
greater than the sum of their separate effects. It can be considered a natural “straight” …

[HTML][HTML] Thymoquinone as a potential adjuvant therapy for cancer treatment: evidence from preclinical studies

AGM Mostofa, MK Hossain, D Basak… - Frontiers in …, 2017 - frontiersin.org
Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to
exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ …

[HTML][HTML] ANRIL: a regulator of VEGF in diabetic retinopathy

AA Thomas, B Feng… - … ophthalmology & visual …, 2017 - iovs.arvojournals.org
Purpose: Long noncoding RNAs (lncRNAs) previously thought to be “dark matter” of the
genome, play key roles in various biological processes. The lncRNA ANRIL is located at a …

[HTML][HTML] Chemopreventive and anticancer effects of thymoquinone: cellular and molecular targets

R Gomathinayagam, JH Ha, M Jayaraman… - Journal of cancer …, 2020 - ncbi.nlm.nih.gov
Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that
are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have …

Thymoquinone inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing NF-κB and MAPKs signaling pathway

D Wang, J Qiao, X Zhao, T Chen, D Guan - Inflammation, 2015 - Springer
Thymoquinone, an active ingredient isolated from Nigella sativa, has been reported to have
anti-inflammatory effects. However, the anti-inflammatory effect of thymoquinone on IL-1β …

Thymoquinone, an active compound of Nigella sativa: role in prevention and treatment of cancer

SA Almatroodi, A Almatroudi, MA Alsahli… - Current …, 2020 - ingentaconnect.com
Background: Cancer is the leading cause of death worldwide and the current mode of
cancer treatment causes side effects on normal cells and are still the key challenges in its' …

Thymoquinone-chemotherapeutic combinations: new regimen to combat cancer and cancer stem cells

AH El-Far, MA Tantawy, SK Al Jaouni… - … Archives of Pharmacology, 2020 - Springer
Cancer is a worldwide disease that causes millions of cases of mortality and morbidity. The
major problem associated with the cancer is its resistance to conventional therapy and a …

[HTML][HTML] Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

F Sheikhnia, V Rashidi, H Maghsoudi… - Cancer cell …, 2023 - Springer
Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide.
Thymoquinone (TQ) is a natural compound of Nigella sativa that has been used in traditional …

[HTML][HTML] Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

Z Fatfat, M Fatfat, H Gali-Muhtasib - World journal of clinical …, 2021 - ncbi.nlm.nih.gov
The long-term success of standard anticancer monotherapeutic strategies has been
hampered by intolerable side effects, resistance to treatment and cancer relapse. These …

[HTML][HTML] Nettle tea inhibits growth of acute myeloid leukemia cells in vitro by promoting apoptosis

MH Hodroj, NH Al Bast, RI Taleb, J Borjac, S Rizk - Nutrients, 2020 - mdpi.com
Urtica dioica (UD), commonly known as “stinging nettle”, is a herbaceous flowering plant that
is a widely used agent in traditional medicine worldwide. Several formulations of UD leaf …