Introduced in the late 1950s, polyenes represent the oldest family of antifungal drugs. The
discovery of amphotericin B and its therapeutic uses is considered one of the most important …

Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …

We reviewed the licensed antifungal drugs and summarized their mechanisms of action,
pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1 …

The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in
human cells makes this component an attractive target for antifungal development. The host …

Role of biofilm in disease development and enhance tolerance to antifungal drugs among
Candida species has necessitated search for new anti-fungal treatment strategy …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Drug resistance derived from extracellular vesicles (EVs) is an increasingly important
research area but has seldom been described regarding fungal pathogens. Here, we …

The polyene antifungal amphotericin B (AmB) exerts a powerful and broad activity against a
vast array of fungi and in general displays a remarkably low rate of antimicrobial resistance …

Candida albicans is considered as the leading species causing vulvovaginal candidiasis.
Numerous virulence determinants and escalating resistance to antifungal therapy have …

Antifungal resistance in humans, animals, and the environment is an emerging problem.
Among the different fungal species that can develop resistance, Candida tropicalis is …