The diversity and breadth of cancer cell fatty acid metabolism

SR Nagarajan, LM Butler, AJ Hoy - Cancer & Metabolism, 2021 - Springer
Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

K Nyame, A Hims, A Aburous, NN Laqtom, W Dong… - Molecular Cell, 2024 - cell.com
Batten disease, the most prevalent form of neurodegeneration in children, is caused by
mutations in the CLN3 gene, which encodes a lysosomal transmembrane protein. CLN3 …

Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C

R Fan, F Zhao, Z Gong, Y Chen, B Yang, C Zhou… - Nature …, 2023 - nature.com
Non-specific phospholipase C (NPC) hydrolyzes major membrane phospholipids to release
diacylglycerol (DAG), a potent lipid-derived messenger regulating cell functions. Despite …

Phospholipase A2 Drives Tumorigenesis and Cancer Aggressiveness through Its Interaction with Annexin A1

L Vecchi, TG Araujo, FVPV Azevedo, STS Mota… - Cells, 2021 - mdpi.com
Phospholipids are suggested to drive tumorigenesis through their essential role in
inflammation. Phospholipase A2 (PLA2) is a phospholipid metabolizing enzyme that …

Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity

W Jiao, Y Sang, X Wang, S Wang - Food Chemistry, 2023 - Elsevier
This study investigated the ability of 6-shogaol to reduce obesity in C57BL/6J mice fed with
high-fat diet (HFD). After 12 weeks of 6-shogaol (20, 40, 60 mg/kg/2 days) intervention …

Scorpion venomics: a 2019 overview

JI Cid-Uribe, JI Veytia-Bucheli… - Expert review of …, 2020 - Taylor & Francis
Introduction: A few scorpions are dangerous to humans. Their medical relevance was the
initial driving force for venom research. By classical biochemistry and molecular cloning …

Dynamic Changes in the Microbial Community and Metabolite Profile during the Pile Fermentation Process of Fuzhuan Brick Tea

MM Le, LW Zhong, ZW Ren, MQ An… - Journal of Agricultural …, 2023 - ACS Publications
The pile fermentation process of Fuzhuan brick tea is unique in that it involves preheating
without the use of starter cultures. The detailed metabolite changes and their drivers during …

Industrial uses of phospholipases: current state and future applications

S Cerminati, L Paoletti, A Aguirre, S Peirú… - Applied microbiology …, 2019 - Springer
Phospholipids play a central role in all living organisms. Phospholipases, the enzymes
aimed at modifying phospholipids, are consequently widespread in nature and play diverse …

Effect of different degumming processes on the retention of bioactive components, acylglycerol and phospholipid composition of rapeseed oil

Z Li, W Wang, X Liu, S Qi, D Lan, Y Wang - Process Biochemistry, 2023 - Elsevier
Rapeseed oil is enriched with nutrients, and its quality is significantly influenced by different
processes. However, few studies have systematically investigated the correlation between …