Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Current drug therapy and pharmaceutical challenges for Chagas disease
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …
Investigation and correlation of drug polymer miscibility and molecular interactions by various approaches for the preparation of amorphous solid dispersions
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …
(PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene …
[HTML][HTML] ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity
LR de Moura Ferraz, AÉGA Tabosa… - Scientific reports, 2020 - nature.com
Chagas disease (CD), caused by the flagellate protozoan Trypanosoma cruzi, is one of the
major public health problems in developing countries. Benznidazole (BNZ) is the only drug …
major public health problems in developing countries. Benznidazole (BNZ) is the only drug …
[HTML][HTML] Molecular interactions in solid dispersions of poorly water-soluble drugs
TTD Tran, PHL Tran - Pharmaceutics, 2020 - mdpi.com
Physicochemical characterization is a crucial step for the successful development of solid
dispersions, including the determination of drug crystallinity and molecular interactions …
dispersions, including the determination of drug crystallinity and molecular interactions …
Solid dispersion of efavirenz in PVP K-30 by conventional solvent and kneading methods
LDS Alves, MFLR Soares, CT de Albuquerque… - Carbohydrate …, 2014 - Elsevier
Efavirenz (EFV) used as a part of the treatment of first choice in antiretroviral therapy for
AIDS has low aqueous solubility and presents problems of absorption. We thus initially …
AIDS has low aqueous solubility and presents problems of absorption. We thus initially …
First century of chagas' disease: An overview on novel approaches to nifurtimox and benznidazole delivery systems
CJ Salomon - Journal of Pharmaceutical Sciences, 2012 - Elsevier
Hundred years after the discovery of Chagas' disease, there is a lack of effective treatment to
control this neglected disease caused by the parasite Trypanosoma cruzi. The transmission …
control this neglected disease caused by the parasite Trypanosoma cruzi. The transmission …
Role of molecular interactions for synergistic precipitation inhibition of poorly soluble drug in supersaturated drug–polymer–polymer ternary solution
We are reporting a synergistic effect of combined Eudragit E100 and PVP K90 in
precipitation inhibition of indomethacin (IND) in solutions at low polymer concentration, a …
precipitation inhibition of indomethacin (IND) in solutions at low polymer concentration, a …
A comparison of the crystallization inhibition properties of bile salts
Bile salts are natural surfactants present in the human gastrointestinal tract. Therefore, it is
essential to consider their effect on the dissolution and crystallization tendency of oral drug …
essential to consider their effect on the dissolution and crystallization tendency of oral drug …
Development and characterization of benznidazole nano-and microparticles: a new tool for pediatric treatment of Chagas disease?
Benznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many
countries. However, its low water solubility produces low and/or variable oral bioavailability …
countries. However, its low water solubility produces low and/or variable oral bioavailability …