Many biological processes result from the effect of mechanical forces on macromolecular
structures and on their interactions. In particular, the cell shape, motion, and differentiation …

Multidomain proteins with long flexible linkers and full-length intrinsically disordered
proteins (IDPs) are best defined as an ensemble of conformations rather than a single …

Extreme external electric fields have been reported to disrupt the tertiary structure of stably
folded proteins; however, the effects of weaker electric fields on many biomolecules …

Although it is known that various intramolecular interactions determine protein mechanical
stability, a detailed molecular-level understanding of the key regulators of protein …

Single-molecule force spectroscopy (smFS) is a powerful approach to studying molecular
self-organization. However, the coupling of the molecule with the ever-present experimental …

摘要翻译过程中新生多肽链的正确折叠是蛋白质具备生物学活性的基石, 但往往新生多肽链正确
形成空间构象需通过共翻译折叠机制才能实现. 在核糖体翻译mRNA 序列时同义密码子使用 …

Chameleon sequences are amino acid sequences found in several distinct configurations in
experiment. They challenge our understanding of the link between sequence and structure …

Free energy profiles form the cornerstone in the study of protein folding and function. In this
study, the free energy profile of SUMO1 protein is directly reconstructed using an extension …

Single molecule force-spectroscopy techniques have granted access to unprecedented
molecular-scale details about biochemical and biological mechanisms. However, the …

Single molecule force-spectroscopy techniques have granted access to unprecedented
molecular-scale details about biochemical and biological mechanisms. However, the …