Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

The chemogenetic technology designer receptors exclusively activated by designer drugs
(DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and …

Escaping from imminent danger is an instinctive behaviour that is fundamental for survival,
and requires the classification of sensory stimuli as harmless or threatening. The absence of …

Sleep interacts reciprocally with immune system activity, but its specific relationship with
microglia—the resident immune cells in the brain—remains poorly understood. Here, we …

The output of cortical columns is routed to different downstream targets via distinct pathways:
cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in …

Abstract Muscarinic Designer Receptors Exclusively Activated by Designer Drugs
(DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation …

Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …