Abstract The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It
is a highly conserved evolutionary pathway of signal transmission from the cell membrane to …

Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Basal cell carcinoma (BCC) is the most common human cancer and represents a growing
public health care problem. Several tumor suppressor genes and proto-oncogenes have …

Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

The mechanisms that control cell proliferation and cell differentiation during morphogenesis
of the endochondral skeleton of vertebrates are poorly understood. Indian hedgehog (Ihh) …

Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling
pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an …

Why are tumours heterogeneous, in terms of cell phenotype and proliferative potential, even
in cases in which all cells are derived from a single clone? Ongoing mutagenesis can …

Solar radiation induces acute and chronic reactions in human and animal skin. Chronic
repeated exposures are the primary cause of benign and malignant skin tumors, including …