[HTML][HTML] Structure, function, and regulation of the blood-brain barrier tight junction in central nervous system disorders
JJ Lochhead, J Yang, PT Ronaldson… - Frontiers in physiology, 2020 - frontiersin.org
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …
critical to neuronal function while simultaneously excluding neurotoxic substances from the …
[HTML][HTML] Biology and models of the blood–brain barrier
The blood–brain barrier (BBB) is one of the most selective endothelial barriers. An
understanding of its cellular, morphological, and biological properties in health and disease …
understanding of its cellular, morphological, and biological properties in health and disease …
Single-cell dissection of the human brain vasculature
Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …
and in understanding neurodegeneration and drug delivery to the central nervous system …
[HTML][HTML] The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …
detected in patients' brain tissues, its entry routes and resulting consequences are not well …
[HTML][HTML] Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications
The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate
Cells derived from pluripotent sources in vitro must resemble those found in vivo as closely
as possible at both transcriptional and functional levels in order to be a useful tool for …
as possible at both transcriptional and functional levels in order to be a useful tool for …
[HTML][HTML] Transcriptomic comparison of human and mouse brain microvessels
HW Song, KL Foreman, BD Gastfriend, JS Kuo… - Scientific reports, 2020 - nature.com
The brain vasculature maintains brain homeostasis by tightly regulating ionic, molecular,
and cellular transport between the blood and the brain parenchyma. These blood–brain …
and cellular transport between the blood and the brain parenchyma. These blood–brain …
[HTML][HTML] The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy
Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …
Bridging barriers: a comparative look at the blood–brain barrier across organisms
NM O'Brown, SJ Pfau, C Gu - Genes & development, 2018 - genesdev.cshlp.org
The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …
brain and is essential for regulating the neural microenvironment. Here, we describe how …
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …
gut microbiota is a key player in communication between these two distant organs. Yet, the …