The extracellular matrix in development
DAC Walma, KM Yamada - Development, 2020 - journals.biologists.com
As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …
both physical support and signaling regulation to cells. Some ECM molecules provide a …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
[HTML][HTML] Actin-based force generation and cell adhesion in tissue morphogenesis
The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …
Unravelling cell migration: defining movement from the cell surface
F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
[HTML][HTML] Generation of stress fibers through myosin-driven reorganization of the actin cortex
JI Lehtimäki, EK Rajakylä, S Tojkander, P Lappalainen - Elife, 2021 - elifesciences.org
Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
[HTML][HTML] Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton
The filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical
actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of …
actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of …
Direct evidence that tumor cells soften when navigating confined spaces
The mechanical properties of cells strongly regulate many physiological and pathological
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
Tissue mechanics, an important regulator of development and disease
A growing body of work describes how physical forces in and around cells affect their
growth, proliferation, migration, function and differentiation into specialized types. How cells …
growth, proliferation, migration, function and differentiation into specialized types. How cells …
[HTML][HTML] Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
S Chakraborty, D Sampath, MO Yu Lin, M Bilton… - Nature …, 2021 - nature.com
An orchestrated wound healing program drives skin repair via collective epidermal cell
proliferation and migration. However, the molecular determinants of the tissue …
proliferation and migration. However, the molecular determinants of the tissue …
[HTML][HTML] Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments
Contractile actomyosin bundles are key force-producing and mechanosensing elements in
muscle and non-muscle tissues. Whereas the organization of muscle myofibrils and …
muscle and non-muscle tissues. Whereas the organization of muscle myofibrils and …