Lipid nanoparticles (LNP) have been instrumental in the success of mRNA vaccines and
have opened up the field to a new wave of therapeutics. However, what is ahead beyond the …

New strategies to potentially improve drug safety and efficacy emerge with allosteric
programs. Biased allosteric modulators can be designed with high subtype selectivity and …

Toxicology is an essential part of any drug development plan. Circumnavigating the risk of
failure because of a toxicity issue can be a challenge, and failure in late development is …

The role that physicochemical properties play toward increasing the likelihood of toxicity
findings in in vivo studies has been well reported, albeit sometimes with different …

We conducted an analysis on screening data generated from 1445 compounds against a
panel of 130 enzymes, ion channels, and receptors to assess secondary pharmacological …

Despite the recent advances in the life sciences and the remarkable investment in drug
discovery research, the success rate of small-molecule drug development remains low …

Breast cancer cases have recorded an increase for the past decade globally. Currently,
available treatments affect patients both physically and mentally, prompting the development …

SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an
orally available nonpeptide selective SST5 agonist may be used to effectively manage the …

The chapter summarizes numerous studies linking molecular properties to pharmacological
promiscuity, ie, the unintended activity of compounds at non‐therapeutic targets. In …

Gelation is a common phenomenon in which a large amount of solvent is immobilized in a
network made up of relatively small amounts of substrate. With properties of both solid and …