Human breast cancer is usually caused by genetic alterations of somatic cells of the breast,
but occasionally, susceptibility to the disease is inherited. Mapping the genes responsible …

The human genome contains approximately 50,000 copies of an interspersed repeat with
the sequence (dT-dG) n, where n= approximately 10-60. In humans,(TG) n repeats have …

Summary Charcot-Marie-Tooth disease type 1 A (CMTi A) was localized by genetic mapping
to a 3 CM interval on human chromosome 17~. DNA markers within this interval revealed a …

Williams syndrome (WS) is a developmental disorder affecting connective tissue and the
central nervous system. A common feature of WS, supravalvular aortic stenosis, is also a …

Elsewhere in this issue of Genomics is the first consortium map, that of chromosome 10, from
the CEPH collabaration to map the human genome genetically. The map is truIy a …

Familial breast cancer has been linked to the D17S74 locus on chromosome 17q. To
confirm this finding and to investigate whether ovarian cancer is also linked to this locus, five …

Abstract p53 gene structure and chromosome 17p alleles were studied in the three human
prostate cancer cell lines, LNCaP, DU‐145, and PC‐3. Our laboratory has two separate …

Hypervariable minisatellites can be amplified from human DNA by the polymerase chain
reaction, using primers from DNA flanking the minisatellite to amplify the entire block of …

Abstract Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited
peripheral neuropathy in humans, characterized electrophysiologically by decreased nerve …

The angiotensin converting enzyme (ACE) is a key component of the renin angiotensin
system that contributes to the regulation of blood pressure (BP). Recent demonstration of …