Tumour budding in solid cancers

A Lugli, I Zlobec, MD Berger, R Kirsch… - Nature Reviews Clinical …, 2021 - nature.com
Tumour budding is an emerging prognostic biomarker in colorectal cancer (CRC) and other
solid cancers. Tumour buds are usually defined as isolated single cancer cells or clusters of …

The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives

J Majidpoor, K Mortezaee - Clinical Immunology, 2021 - Elsevier
Colorectal cancer (CRC), and breast, ovarian, pancreatic and prostate cancers are generally
considered as low immune-reactive cancers that represent either limited infiltration of …

Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response

Y Wang, Y Liang, H Xu, X Zhang, T Mao, J Cui, J Yao… - Cell discovery, 2021 - nature.com
The current pathological and molecular classification of pancreatic ductal adenocarcinoma
(PDAC) provides limited guidance for treatment options, especially for immunotherapy …

Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer

SA Väyrynen, J Zhang, C Yuan, JP Väyrynen… - Clinical Cancer …, 2021 - AACR
Purpose: Although abundant myeloid cell populations in the pancreatic ductal
adenocarcinoma (PDAC) microenvironment have been postulated to suppress antitumor …

The immune landscape of human pancreatic ductal carcinoma: key players, clinical implications, and challenges

M Muller, V Haghnejad, M Schaefer, G Gauchotte… - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …

Current limitations and novel perspectives in pancreatic cancer treatment

S Robatel, M Schenk - Cancers, 2022 - mdpi.com
Simple Summary This review article presents a synopsis of the key clinical developments,
their limitations, and future perspectives in the treatment of pancreatic cancer. In the first part …

Electroporation and immunotherapy—unleashing the abscopal effect

TF Justesen, A Orhan, H Raskov, C Nolsoe, I Gögenur - Cancers, 2022 - mdpi.com
Simple Summary Electrochemotherapy and irreversible electroporation are primarily used
for treating patients with cutaneous and subcutaneous tumors and pancreatic cancer …

Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept

W Luo, T Wen, X Qu - Journal of Experimental & Clinical Cancer Research, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …

Evaluation of tumour infiltrating lymphocytes in luminal breast cancer using artificial intelligence

S Makhlouf, N Wahab, M Toss, A Ibrahim… - British Journal of …, 2023 - nature.com
Abstract Background Tumour infiltrating lymphocytes (TILs) are a prognostic parameter in
triple-negative and human epidermal growth factor receptor 2 (HER2)-positive breast cancer …

Correlation between lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and tumor-infiltrating lymphocytes …

C Gawiński, W Michalski, A Mróz, L Wyrwicz - Biology, 2022 - mdpi.com
Simple Summary Colorectal cancer (CRC) is one of the most common cancers worldwide.
Novel markers have been investigated in order to better predict the course of disease and …