Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Metabolic reprogramming is a hallmark of cancer. However, mechanisms underlying
metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are …

Availability of the essential amino acid methionine affects cellular metabolism and growth,
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …

Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic,
biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support …

As a fundamental process of the programmed cell death, apoptosis has endowed
nanomedicine broad horizons to treat tumor. However, apoptosis-resistance elicited by …

Tumor cells possess complex immune evasion mechanisms to evade immune system
attacks, primarily through metabolic reprogramming, which significantly alters the tumor …

Metabolism and mRNA translation represent critical steps involved in modulating gene
expression and cellular physiology. Being the most energy-consuming process in the cell …

During their quest for growth, adaptation, and survival, cancer cells create a favorable
environment through the manipulation of normal cellular mechanisms. They increase …