Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

More than 25 years of research and preclinical validation have defined EphA2 receptor
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …

Experimental structures are leveraged through multiple sequence alignments, or more
generally through homology-based inference (HBI), facilitating the transfer of information …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

Eph receptor tyrosine kinases and their ephrin ligands regulate cell navigation during
normal and oncogenic development. Signaling of Ephs is initiated in a multistep process …

Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases
mediating cell-cell communication. Upon activation, they form signaling clusters. We report …

Human γδ T cells contribute to tissue homeostasis and participate in epithelial stress
surveillance through mechanisms that are not well understood. Here, we identified ephrin …

The obligate intracellular bacterium Chlamydia trachomatis invades into host cells to
replicate inside a membrane-bound vacuole called inclusion. Multiple different host proteins …

The Eph receptors and their ephrin ligands play crucial roles in a large number of cell–cell
interaction events, including those associated with axon pathfinding, neuronal cell migration …

The EphA2 receptor tyrosine kinase is capable of activating multiple diverse signaling
pathways with roles in processes such as tissue homeostasis and cancer. EphA2 is known …