The nuclear factor‐κB (NF‐κB) family of transcription factors plays important roles in various
biological processes including apoptosis, stress response, immunity, and inflammation. NF …

The role of interferon (IFN)-γ in multiple sclerosis (MS) and its animal model, experimental
autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than …

Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing
autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ …

Foxp3-expressing regulatory T cells (Tregs) play a crucial role in maintaining immune
tolerance and homeostasis. One of the key issues for understanding Treg immunobiology is …

Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central
nervous system (CNS) and one of the leading causes of neurological deficits and disability …

Mesenchymal stem/stromal cells (MSC) have been tested in a significant number of clinical
trials, where they exhibit regenerative and repair properties directly through their …

Transendothelial migration (TEM) of Th1 and Th17 cells across the blood–brain barrier
(BBB) has a critical role in the development of experimental autoimmune encephalomyelitis …

Traditionally, T cells were CD4+ helper or CD8+ cytotoxic T cells, and with antibodies, they
were the soldiers of immunity. Now, many functionally distinct subsets of activated CD4+ and …

When seen in its entirety, the animal model experimental autoimmune encephalomyelitis
(EAE) bears signifi‑cant similarities to multiple sclerosis (MS) and its different varieties …

The Fas/FasL (CD95/CD178) system is required for immune regulation; however, it is
unclear in which cells, when, and where Fas/FasL molecules act in the immune system. We …