Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …
rising, as younger age mortality declines. However, the age-specific incidence of dementia …
The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
[HTML][HTML] The β-secretase BACE1 in Alzheimer's disease
BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β …
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β …
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
Tau deposition patterns are associated with functional connectivity in primary tauopathies
N Franzmeier, M Brendel, L Beyer, L Slemann… - Nature …, 2022 - nature.com
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease
N Franzmeier, A Dewenter, L Frontzkowski… - Science …, 2020 - science.org
In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau
spreading pattern that does, however, not capture interindividual variability in tau deposition …
spreading pattern that does, however, not capture interindividual variability in tau deposition …
Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
In Alzheimer's disease (AD), younger symptom onset is associated with accelerated disease
progression and tau spreading, yet the mechanisms underlying faster disease manifestation …
progression and tau spreading, yet the mechanisms underlying faster disease manifestation …
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease
Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's
disease, but the functional brain mechanisms that support cognitive resilience remain …
disease, but the functional brain mechanisms that support cognitive resilience remain …
Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease
In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease
J Gonneaud, AT Baria, A Pichet Binette… - Nature …, 2021 - nature.com
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …