As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have
been extensively reviewed since its discovery over 40 years ago. Here, we will describe …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammatory
back pain and spinal ankylosis due to pathological new bone formation. Here, we identified …

Articular cartilage, composed of collagen type II as a major extracellular matrix and
chondrocyte as a unique cell type, is a specialized connective tissue without blood vessels …

Objective The aim of this study was to identify the role of Piezo1-mediated
mechanotransduction in entheseal pathological new bone formation and to explore the …

Purpose of the Review Emerging evidence has shown that ankylosing spondylitis fibroblasts
(ASFs) act as crucial participants in inflammation and abnormal ossification in ankylosing …

The reconstruction of bone defects following bone tumor resection pose significant
challenges, including high risks for tumor recurrence. To address these challenges, we …

(1) Background: Injury repair is a complex physiological process in which multiple cells and
molecules are involved. Tenascin-C (TNC), an extracellular matrix (ECM) glycoprotein, is …

Previous studies have revealed cellular heterogeneity in intervertebral discs (IVDs).
However, the cellular and molecular alteration patterns of cell populations during …