The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

DNA-methylation patterns are important for regulating genome functions, and are
determined by the enzymatic processes of methylation and demethylation. The …

The pattern of DNA methylation plays an important role in regulating different genome
functions. To test the hypothesis that DNA methylation is a reversible biochemical process …

Cancer is a process driven by the accumulation of abnormalities in gene function. While
many of these changes are genetic, epigenetically mediated changes in gene expression …

The changing pattern of granulosa cell expression of inhibin/activin subunits and follistatin
during follicle development and their differential regulation by extrinsic and intraovarian …

DNA methylation marks, a key modification of imprinting, are erased in primordial germ cells
and sex specifically re-established during gametogenesis. Abnormal epigenetic …

Embryonic development in mammals is distinct from that in other vertebrates because it
depends on a small number of imprinted genes that are specifically expressed from either …

Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program
tissue specific patterns of gene expression. Cells, including neurons, undergo massive …